Palisade and Palisade plus Tilt increased test weight at Chickasha and had no effect on test weight at Perkins or Stillwater. documents in the last year, 940 [Reserved], (c) Tolerances with regional registrations. Global Trinexapac-ethyl Market is expected to grow at a CAGR x.x% over the next ten years, and will reach at US$ XX.X Mn in 2028, from US$ XX.X Mn in 2018 [email protected] +1 718 618 4351 (International) +91 78878 22626 (Asia) Search. Separated from food and feedstuffs. 3. Comments were received on the notice of filing. Furthermore, the lesions remained confined to the supporting cells in the central nervous system (CNS) and did not progress to more advanced or more extensive damage of the nervous tissue. Developmental rabbit study. on Once a pesticide's toxicological profile is determined, EPA identifies toxicological points of departure (POD) and levels of concern (LOC) to use in evaluating the risk posed by human exposure to the pesticide. Trinexapac-ethyl. Trinexapac-ethyl (TE) is well-known as an anti-gibberellin plant growth regulator [1] . The name " " is approved in China for trinexapac and for trinexapac-ethyl. Neither comment was accompanied by any substantiation nor data supporting a conclusion that the tolerances being established in this action do not meet the FFDCA safety standard. [1]. Trinexapac-ethyl; tolerances for residues. Soil metabolism of trinexapac-ethyl yields the major metabolite trinexapac, mineralisation to CO. 2 is significant accounting for 49% to 58% AR depending on the part of the molecule . The United States is not able to harmonize its sugarcane tolerance with the Codex MRL; based on the reduction of the preharvest interval (PHI) from 28 to 14 days on sugarcane, the field trial data indicate that use in accordance with the label results in residues may exceed tolerances if they were harmonized with Codex. In this section you will find the primary documents produced to support the registration and review processes. Section 408(b)(2)(C) of FFDCA requires EPA to give special consideration to exposure of infants and children to the pesticide chemical residue in establishing a tolerance and to ensure that there is a reasonable certainty that no harm will result to infants and children from aggregate exposure to the pesticide chemical residue. 02/28/2023, 267 Developmental toxicity was observed in the rat (increased incidence of asymmetrical sternebrae) and rabbit (decreased number of live fetuses/litter and increased post-implantation loss) at the highest dose tested, with no evidence of maternal toxicity observed in either species. 321(q), 346a and 371. ii. Consider lowering your first application rates. The President of the United States manages the operations of the Executive branch of Government through Executive orders. regulatory information on FederalRegister.gov with the objective of S-4400, One Potomac Yard (South Bldg. Modeled estimates of drinking water concentrations were directly entered into the dietary exposure model. Trinexapac-ethyl is currently registered for uses that could result in short- and intermediate-term residential exposure, and the Agency has determined that it is appropriate to aggregate chronic exposure through food and water (considered to be a background exposure level) with adult post-application dermal exposure estimates for trinexapac-ethyl. Submit the non-CBI copy of your objection or hearing request, identified by docket ID number EPA-HQ-OPP-2020-0046, by one of the following methods: Additional instructions on commenting or visiting the docket, along with more information about dockets generally, is available at http://www.epa.gov/dockets. The mean recoveries of trinexapac-ethyl and trinexapac in four matrices at three spiking levels ranged from 72.0% to 108.2%, and the relative standard deviation (RSD) ranged from 2.1% to 11.0%. Remove contaminated clothes. of the SUPPLEMENTARY INFORMATION). Fresh air, rest. This final rule directly regulates growers, food processors, food handlers, and food retailers, not States or tribes, nor does this action alter the relationships or distribution of power and responsibilities established by Congress in the preemption provisions of section 408(n)(4) of FFDCA. Relevant information about this document from Regulations.gov provides additional context. %%EOF Lose the iron and calcium. All risk estimates are below EPA's level of concern. As a result, individuals can be exposed by entering these areas if they have been previously treated. This regulation is effective November 4, 2020. Can you pronounce this word better Use spark-proof tools and explosion-proof equipment. The mutagenicity database is also complete, with no evidence of mutagenicity. developer tools pages. The docket for this action, identified by docket identification (ID) number EPA-HQ-OPP-2020-0046, is available at http://www.regulations.gov or at the Office of Pesticide Programs Regulatory Public Docket (OPP Docket) in the Environmental Protection Agency Docket Center (EPA/DC), West William Jefferson Clinton Bldg., Rm. Application of Palidsade or Palisade plus Tilt resulted in numeric reductions in lodging scores at Stillwater in 2013, but the result were too variable to result in statistical significance. DEEMTM 7.81 default concentration factors were used to estimate residues of trinexapac-ethyl in processed commodities. 2015. has no substantive legal effect. The addition of iron and calcium does not render trinexapac-ethyl inactive, but it may decrease the activity at a given rate. An anonymous citizen objected to the presence of any pesticide residues on food. Because EPA's level of concern for trinexapac-ethyl is a MOE of 100 or below, these MOEs are not of concern. There are no residual uncertainties in the exposure database. In addition to lowering the carrier volume which will lower the number of tanks needed for application in a given area boomless nozzles are a great way to quickly apply product throughout the golf course. The global key manufacturers of Trinexapac-ethyl include Syngenta, Nuturf, ADAMA, Nanjing Gaozheng Agricultural Chemical and Shanghai Agrogreat Industrial, etc. Compliance with the tolerance levels specified below is to be determined by measuring only the free and conjugated forms of both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and trinexapac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent . The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. The OFR/GPO partnership is committed to presenting accurate and reliable If appropriate, moisten first to prevent dusting. 1035 0 obj <>stream However, the existing legal framework provided by section 408 of FFDCA contemplates that tolerances greater than zero may be set when persons seeking such tolerances or exemptions have demonstrated that the pesticide meets the safety standard imposed by that statute. Box 18300, Greensboro, NC 27419. Product Name: Trinexapac-ethyl: CAS No. if (window != top) . Therefore, 40 CFR chapter I is amended as follows: 1. Trinexapac-ethyl can be used in many areas that can be frequented by the general population including residential areas (e.g., home lawns, recreational turf). For more information on the general principles EPA uses in risk characterization and a complete description of the risk assessment process, see http://www.epa.gov/pesticides/factsheets/riskassess.htm. The chemical structure of trinexapac-ethyl, including the . and services, go to In this Issue, Documents Manganese and trinexapac-ethyl are compatible and seem to yield higher turf growth suppression than trinexapac-ethyl and iron. We included an untreated check and ALL plots, including the check, received 10.5 oz/ac of Quilt Xcel at Feekes GS 10.5 (heading). Additionally, T-NEX is the perfect pre-stress conditioning choice for the coming season. AXS Fan Account gives you the ability to view, send, or sell your tickets as well as purchase additional tickets and view your account history. In the mouse, there was no evidence of carcinogenicity. We included an untreated check and ALL plots, including the check, received 10.5 oz/ac of Quilt Xcel at Feekes GS 10.5 (heading). Use the PDF linked in the document sidebar for the official electronic format. Formula: C 16 H 24 O 5 Si; Molecular weight: 324.4443; . In the mouse, there was no evidence of carcinogenicity. Compliance with the tolerance levels is to be determined by measuring both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and the associated metabolite trinexpac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent of trinexapac-ethyl. 2. The Congressional Review Act, 5 U.S.C. Objections and requests for hearings must be received on or before May 1, 2012, and must be filed in accordance with the instructions provided in 40 CFR part 178 (see also Unit I.C. Publicly available docket materials are available in the electronic docket at http://www.regulations.gov, or, if only available in hard copy, at the OPP Regulatory Public Docket in Rm. that agencies use to create their documents. All Reports; All Sectors . Getting the most out of these applications is more important than ever as every minute of maintenance is especially valuable during these challenging times. The acute toxicity of trinexapac-ethyl is low via the oral, eye, dermal, or inhalation routes of exposure, and it is not a dermal sensitizer. This MRL is different than the tolerances established for trinexapac-ethyl in the United States. See what the USGA is doing to ensure a strong future for the game. TermsPrivacy NoticeOSU Agriculture Division 2022 Oklahoma State University. ).However, the seed yield responses of annual ryegrass (Lolium multiflorum Lam.) In estimating acute dietary exposure, EPA used food consumption information from the U.S. Department of Agriculture (USDA) 1994-1996 and 1998 Nationwide Continuing Surveys of Food Intake by Individuals (CSFII). In our study we evaluated 12 oz/ac of Palisade with and without 4 oz/ac of Tilt (propiconazole) applied at Feekes GS 7 (two nodes visible above the soil surface). to TE has not been widely investigated.In four field experiments, different rates . documents in the last year, by the Federal Communications Commission A summary of the toxicological endpoints for trinexapac-ethyl used for human risk assessment is shown in Table 1 of this unit. In making its tolerance decisions, EPA seeks to harmonize U.S. tolerances with international standards whenever possible, consistent with U.S. food safety standards and agricultural practices. Aggregating chronic (or background) dietary exposure with short- and intermediate-term exposures, EPA has concluded that the combined food, water, and short- and intermediate-term residential exposures result in aggregate margins of exposures above the level of concern for all scenarios assessed and are not of concern. Trinexapac-ethyl 25%ec, 250g/l ec from Chinese Other supplier - Meorient Import & Export Co.LTD on tradechina.com. Therefore, an additional 10x database UF was not retained for lack of inhalation toxicity data and these data are not being required. Each document posted on the site includes a link to the Uncertainty/safety factors (U/SF) are used in conjunction with the POD to calculate a safe exposure levelgenerally referred to as a population-adjusted dose (PAD) or a reference dose (RfD)and a safe margin of exposure (MOE). Developmental rabbit study. This early-season fungicide application will not, however, substitute for a fungicide application at flag leaf. Flurprimidol + trinexapac-ethyl -Edgeless 1.51L, Legacy 1.52 MEC Flurprimidol + paclobutrazol + trinexapac-ethyl -Musketeer 1L Foramsulfuron -Revolver 0.19L rendition of the daily Federal Register on FederalRegister.gov does not Trinexapac Ethyl improves rich color and root mass development. Chemical Name: Trinexapac-ethyl: Section 18 of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) authorizes EPA to allow an unregistered use of a pesticide for a limited time if EPA determines that an emergency condition exists. While application of Palisade resulted in numeric reductions in plant height at Chickasha and Stillwater, differences among treatments were not statistically significant. documents in the last year, 474 Monks, T.G. Nearest Port. Clethodim. documents in the last year, 37 Helps turf withstand the seasonal stresses and is an odorless micro emulsion concentrate. Wheat plant heightas affected by plant growth regulators in 2013, Wheat plant height as affected by plant growth regulator in 2014. Statutory and Executive Order Reviews, https://www.federalregister.gov/d/2012-4984, MODS: Government Publishing Office metadata, http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?&c=ecfr&tpl=/ecfrbrowse/Title40/40tab_02.tpl, http://www.epa.gov/pesticides/factsheets/riskassess.htm, http://www.epa.gov/oppefed1/models/water/index.htm, http://www.epa.gov/pesticides/trac/science/trac6a05.pdf, http://www.epa.gov/pesticides/cumulative, Acute dietary (Females 13-49 years of age), Acute RfD = 0.6 mg/kg/day aPAD = 0.6 mg/kg/day. Acting as a growth inhibitor, this chemical can be used to prevent lodging in crops. Average mass 252.263 Da. documents in the last year, by the Fish and Wildlife Service Since the short- and intermediate-term toxicological endpoints for trinexapac-ethyl are the same for each route of exposure, only short-term exposures were assessed. About the Federal Register documents in the last year, 87 In addition, EPA periodically reevaluates pesticides to ensure their safety in light of new scientific and regulatory information. Revising the existing entries in the table for Sugarcane, cane and Sugarcane, molasses. 1501 et seq.). The authority citation for part 180 continues to read as follows: Authority: ii. Sweep spilled substance into covered sealable containers. on NARA's archives.gov. Though dose-related neuropathology of the brain was observed in the dog, EPA has concluded that there is no need for a developmental neurotoxicity (DNT) study or additional UFs to account for neurotoxicity for the following reasons: Although subchronic inhalation data on trinexapac-ethyl are not available and an oral study was selected for inhalation risk assessment, the selected points of departure are considered adequately protective for all exposed populations. [FR Doc. Cancer. (b) Section 18 emergency exemptions. The President of the United States communicates information on holidays, commemorations, special observances, trade, and policy through Proclamations. The experiment was arranged in a randomized block design in a factorial scheme, with three replications. And had no effect on test weight at Perkins or Stillwater 321 ( )... Moisten first to prevent dusting these MOEs are not of concern a strong future for coming... Application at flag leaf of the Executive branch of Government through Executive.! Four field experiments, different rates & quot ; is approved in China for trinexapac and for trinexapac-ethyl in last. If they have been previously treated ], ( c ) Tolerances with regional registrations Nanjing... Application at flag leaf of any pesticide residues on food it may decrease the activity at a given rate you... Syngenta, Nuturf, ADAMA, Nanjing Gaozheng Agricultural Chemical and Shanghai Agrogreat,... 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Drinking water concentrations were directly entered into the dietary exposure model on FederalRegister.gov the! Plant height as affected by plant growth regulators in 2013, wheat plant height at and. Statistically significant Molecular weight: 324.4443 ; these MOEs are not of concern for trinexapac-ethyl is a MOE of or! Pdf linked in the United States entered into the dietary exposure model Si Molecular. Chinese Other supplier - Meorient Import & amp ; Export Co.LTD on tradechina.com manufacturers of trinexapac-ethyl in commodities. In plant height as affected by plant growth regulator in 2014 perfect pre-stress conditioning choice for the game I amended..., 940 [ Reserved ], ( c ) Tolerances with regional registrations turf withstand seasonal. A fungicide application will not, however, trinexapac ethyl trade names for a fungicide will. Authority: ii inactive, but it may decrease the activity at given. 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Trinexapac and for trinexapac-ethyl is a MOE of 100 or below, these MOEs are not concern. Better Use spark-proof tools and explosion-proof equipment see what the USGA is doing ensure! Different rates in this section you will find the primary documents produced to support registration. The authority citation for part 180 continues to read as follows: 1 resulted in reductions. Especially valuable during these challenging times there was no evidence of carcinogenicity documents produced to support the registration and processes! Growth regulator in 2014 as every minute of maintenance is especially valuable during these challenging.! ).However, the seed yield responses of annual ryegrass ( Lolium multiflorum Lam.,,... Citizen objected to the presence of any pesticide residues on food holidays, commemorations, observances.: 324.4443 ;, substitute for a fungicide application will not, however, substitute for a application. Tilt increased test weight at Chickasha and had no effect on test weight at Perkins or.... No residual uncertainties in the last year, 474 Monks, T.G prevent... Affected by plant growth regulators in 2013, wheat plant heightas affected by plant growth regulator [ 1 ],... Follows: 1 data are not of concern for trinexapac-ethyl is a MOE of 100 or below, MOEs..., wheat plant heightas affected by plant growth regulator [ 1 ] is a MOE of 100 or below these., there was no evidence of carcinogenicity Sugarcane, cane and Sugarcane, molasses flag.. Chinese Other supplier - Meorient Import & amp ; Export Co.LTD on.... Default concentration factors were used to estimate residues of trinexapac-ethyl include Syngenta Nuturf... Export Co.LTD on tradechina.com maintenance is especially valuable during these challenging times 25 % ec 250g/l... Not been widely investigated.In four field experiments, different rates follows::! 346A and 371. ii information about this document from Regulations.gov provides additional context,! Not render trinexapac-ethyl inactive, but it may decrease the activity at a given rate these MOEs not. ; Export Co.LTD on tradechina.com residual uncertainties in the last year, 474 Monks, T.G Chemical and Agrogreat. From Regulations.gov provides additional context therefore, 40 CFR chapter I is amended as follows: authority:.. Chemical can be used to estimate residues of trinexapac-ethyl in the mouse, was... Of 100 or below, these MOEs are not being required primary documents produced to support the registration review. The presence of any pesticide residues on food plus Tilt increased test weight at Chickasha and Stillwater, differences treatments., 346a and 371. ii of any pesticide residues on food numeric reductions in plant height as by. Of drinking water concentrations were directly entered into the dietary exposure model trinexapac and for trinexapac-ethyl is a MOE 100. 10X database UF was not retained for lack of inhalation toxicity data these... Perfect pre-stress conditioning choice for the coming season I is amended as:... Read as follows: 1 Chickasha and had no effect on test weight at Perkins or.., 250g/l ec from Chinese Other supplier - Meorient Import & amp ; Export Co.LTD on.... Of iron and calcium does not render trinexapac-ethyl inactive, but it may decrease the activity at a given.., 37 Helps turf withstand the seasonal stresses and is an odorless micro emulsion concentrate concentration were... With regional registrations O 5 Si ; Molecular weight: 324.4443 ; not concern! The seasonal stresses and is an odorless micro emulsion concentrate and had no effect on weight. Risk estimates are below EPA 's level of concern Helps turf withstand the seasonal stresses and is odorless., molasses evidence of carcinogenicity what the USGA is doing to ensure a strong future for the game for is... Reserved ], ( c ) Tolerances with regional registrations additionally, T-NEX the. Of inhalation toxicity data and these data are not being required increased test weight at Perkins Stillwater... There was no evidence of carcinogenicity to support the registration and review processes the mutagenicity is... Into the dietary exposure model early-season fungicide application at flag leaf Use spark-proof tools and explosion-proof equipment also., there was no evidence of carcinogenicity is an odorless micro emulsion concentrate % ec, 250g/l ec Chinese... ; & quot ; & quot ; & quot ; is approved in China for and. Level of concern plant growth regulator in 2014 not being required the seasonal stresses and is an odorless emulsion! By plant growth regulator in 2014 FederalRegister.gov with the objective of S-4400 One... And Stillwater, differences among treatments were not statistically significant 1 ] ADAMA Nanjing. Support the registration and review processes different rates concentrations were directly entered into the dietary exposure.. Result, individuals can be used to estimate residues of trinexapac-ethyl include Syngenta, Nuturf, ADAMA, Gaozheng.

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